The histochemistry and Histopathology is essential for accurate medical diagnoses and plays a vital role in guiding treatment decisions. The histopathology unit is a specialized laboratory dedicated to the study and diagnosis of diseases through microscopic examination of tissues. It plays a crucial role in identifying abnormalities in cells and tissues, helping biomedical researchers and medical professionals diagnose conditions like cancer, infections, and autoimmune diseases.
Histochemistry plays a crucial role in drug research by helping scientists visualize and analyse the biochemical composition of tissues at a cellular level. It provides insights into how drugs interact with biological systems, aiding in drug development, toxicity assessment, and disease pathology. This unit has served a great role in our research on drug development for filarial infections notably; Loiasis and Onchocerciasis, using small animal models, cattle spp. And none-human primages. Histochemistry is widely used in pharmacology, pathology, and biomedical research to refine drug formulations and improve treatment strategies.

Our Area of Competence
- Disease Diagnosis: Examines tissue samples to detect abnormalities, including infectious and non-infectious disease pathologies.
- Biopsy Analysis: Evaluates tissue removed during surgery or biopsy to confirm medical conditions.
- Cancer Staging and Grading: Determines how advanced and aggressive a tumor is.
- Infection, Inflammation and auto-immune Detection: Identifies bacterial, viral, or fungal infections affecting tissues.
- Research & Medical Advancements: Supports studies on disease mechanisms and new treatments.
- Toxicity and Side Effect Analysis: Detects cellular damage or biochemical changes caused by drug exposure.

Our Achievements
- Contribution to the elucidation of Severe Advent Events following ivermectin treatment of Lao loa and Onchocerciasis co- infected individuals.
- Contribution to the development of new drugs for filariasis, using small animal and cattle models.
- Collaboration with oncology units for diagnosis of tumour and cancer-related pathologies

Some of Our Publications
1. Wanji S, Eyong EJ, Tendongfor N, Ngwa CJ, Esuka EN, Kengne-Ouafo AJ, Datchoua-Poutcheu FR, Enyong P, Agnew D, Eversole RR, Hopkins A, Mackenzie CD. Ivermectin treatment of Loa loa hyper-microfilaraemic baboons (Papio anubis): Assessment of microfilarial load reduction, haematological and biochemical parameters and histopathological changes following treatment. PLoS Negl Trop Dis. 2017 Jul 7;11(7):e0005576. doi: 10.1371/journal.pntd.0005576. PMID: 28686693; PMCID: PMC5533442.
2. Akumtoh DN, Njouendou AJ, Metuge HM, Sjoberg HT, Pionnier NP, Chunda VC, Gandjui NVT, Ndzeshang LB, Fombad FF, Abong RA, Enyong PA, Fru-Cho J, Esum ME, Ritter M, Taylor MJ, Turner JD, Wanji S. Onchocerca ochengi male worms implanted in SCID mice and Gerbil: Relationship between microfilaridermia status of cows, nodular worm viability and fertility and worm survival in the rodents. Exp Parasitol. 2021 Oct;229:108143. doi: 10.1016/j.exppara.2021.108143. Epub 2021 Aug 24. PMID: 34437906; PMCID: PMC8518880.

